What if the next big breakthrough in cancer research was hiding in plain sight—somewhere no one would think to look? That’s exactly what happened when 13-year-old Camarria Williams scooped up a sample of goose droppings from a neighborhood park. What started as a simple STEM project turned into a remarkable scientific discovery that stunned researchers.
Her sample contained Pseudomonas idahoensis, a bacterium that, while not producing antibiotics, led to a surprising discovery—a previously unknown compound called orfamide N. Under the microscope, researchers found that orfamide N was toxic to skin and ovarian cancer cells, slowing their growth. Scientists at the University of Illinois Chicago verified the compound’s effects, adding valuable insight into cancer research.
How a STEM Program Led to a Groundbreaking Discovery
Camarria Williams’ discovery was made possible through the Chicago Antibiotic Discovery Lab, a STEM outreach program in partnership with the Boys & Girls Club. The 14-week project introduced middle school students to real-world research, tasking them with collecting environmental samples to search for new antibiotics.
Williams and her peers examined their samples under microscopes, assisted by a $200,000 research robot from the University of Illinois Chicago’s Institute for Tuberculosis Research. The robot helped catalog and track bacteria with potential medical applications.
Advancing the Research
Her findings were further analyzed by researchers at the University of Illinois Chicago. Jin Yi Tan, a doctoral student in Dr. Brian Murphy’s lab, explained: “For Camarria, she prioritized the bacteria with antibiotic properties. So I followed up on the strains that she prioritized, which is where in the lab I would grow it up and purify the compounds and then do some further testing. And that’s where we found this new compound that had some cytotoxic activity against cancer cell lines.” Through this process, the team found that orfamide N had cytotoxic effects on cancer cells, a discovery that could contribute to future drug development.
Inspiring the Next Generation of Scientists
Dr. Murphy sees this as proof of the power of STEM education. “We want to light a spark inside of them, get them to care about their education, and maybe even be the launching point for the next generation of biomedical researchers,” he said.
- Paclitaxel (Taxol) – Extracted from Pacific yew tree bark, used to treat breast, ovarian, and lung cancers.
- Vincristine and Vinblastine – Derived from the Madagascar periwinkle plant, used for leukemia and lymphoma.
- Actinomycin D – A bacterial-derived chemotherapy drug used for decades.
Like these discoveries, orfamide N broadens scientists’ understanding of how natural compounds interact with cancer cells. While it is not a treatment, its identification underscores the importance of studying nature for medical advancements.
Dr. Brian Murphy, who oversaw the research program, emphasized that Williams’ finding highlights why early STEM education matters. Programs like the Chicago Antibiotic Discovery Lab not only introduce young scientists to research but also contribute to real-world discoveries.
Inclusive STEM initiatives not only enhance individual learning outcomes but also contribute to a more diverse and innovative workforce. Research indicates that such programs can increase students’ sense of belonging and identity within the scientific community, leading to higher engagement and persistence in STEM fields. Moreover, diversity-focused STEM intervention programs have been shown to effectively support underrepresented groups, promoting equity within the scientific community.
By investing in and expanding these programs, we can inspire a new generation of scientists, ensuring continued innovation and progress in various fields.
Simple Ways to Spark Curiosity and Scientific Thinking in Everyday Life
You don’t need a lab or a formal STEM program to start thinking like a scientist. Here are practical ways anyone can nurture curiosity, critical thinking, and a love for discovery—whether for yourself, your kids, or someone you mentor.
Explore Nature Like a Scientist
Take a closer look at the everyday world. Go for a walk and notice insects, trees, or even the sky. Why do certain birds come out at different times? What patterns do you see in the clouds? Observing nature teaches patience and attention to detail—two essential scientific skills.
Use Everyday Tech to Learn Something New
Turn screen time into learning time with apps and websites that make science fun:
- Google Lens – Identify plants, insects, and objects instantly.
- SkyView – Point your phone at the sky to learn about constellations and planets.
- YouTube Channels like Veritasium, SciShow, or Smarter Every Day explain science in engaging ways.
Let Mistakes Happen
Science is all about trial and error. If an experiment “fails” or you can’t find an answer, that’s part of the process! Thomas Edison once said, “I have not failed. I’ve just found 10,000 ways that won’t work.” Encourage problem-solving instead of just getting the “right” answer.
Science Starts with Curiosity
Camarria Williams’ discovery is a reminder that scientific breakthroughs often come from unexpected places. From Alexander Fleming’s accidental discovery of penicillin to Percy Spencer stumbling upon microwave technology, history has shown that curiosity leads to innovation. While orfamide N isn’t a cure, it expands scientific understanding—just as countless small discoveries have paved the way for medical advancements.
Science isn’t just for professionals in labs; it’s for anyone willing to observe, question, and explore. Whether through STEM programs or everyday curiosity, the next breakthrough could come from the most unlikely place. Williams’ journey proves one thing: real discovery begins with simply looking closer.