A well-known over-the-counter drug found in homes across America could be more dangerous than people realize. Tylenol PM, a common nighttime pain reliever, may lead to organ failure if taken too often or in high doses.
The warning comes from Dr. Ethan Melillo, a pharmacist from Rhode Island, who recently shared his concerns online. He cautions that many people assume Tylenol PM is harmless because it’s sold without a prescription.
Let’s explore what makes this sleep aid with acetaminophen potentially harmful and what safer alternatives exist.
What’s Inside Tylenol PM?
Tylenol PM contains two active ingredients:
Acetaminophen, which relieves pain and reduces fever
Diphenhydramine, an antihistamine known for its sedative effect
This OTC sleep and pain medication helps users fall asleep while easing mild aches. Many people use it for discomfort that keeps them awake at night. While it may seem like a simple fix, frequent use can pose serious risks to liver and kidney health.
Hidden Risks to Liver and Kidney Health
Dr. Melillo’s message focuses on how the regular use of Tylenol PM can harm internal organs. He explains that combining acetaminophen and diphenhydramine increases the risk of long-term damage, especially when misused.
Acetaminophen and Liver Damage
Acetaminophen is generally safe at the proper dosage. However, more than 4,000 milligrams per day can cause acute liver failure. People with liver conditions or those who drink alcohol face even greater risk.
In the United States, acetaminophen is one of the leading causes of liver failure. Many people accidentally exceed the safe dose by taking multiple products that contain it.
Diphenhydramine and Its Effects
Diphenhydramine helps with sleep and allergies, but long-term use can cause confusion, dizziness and memory issues, especially in seniors. Some research also suggests it may affect kidney function.
Medications like Tylenol PM, which include this over-the-counter sleep remedy, are not intended for everyday use. Their sedative effects can quickly shift from helpful to harmful.
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Why Many Misuse Tylenol PM Without Realizing
One major concern is that most people don’t realize how easy it is to misuse this drug. Because Tylenol PM is widely available and familiar, it feels safe.
That trust can be misleading. For instance, someone might take Tylenol PM for sleep and also take a cold medicine that contains acetaminophen. Without reading the labels, they could unintentionally exceed the daily limit.
Diphenhydramine presents another issue. Regular use can create tolerance, meaning the same dose becomes less effective. Users then increase the amount or frequency, which increases health risks.
This casual reliance on nighttime pain relievers often leads to long-term use without understanding the consequences.
A Pharmacist’s Warning Sparks Conversation
Dr. Melillo’s online warning has gained attention and opened up a broader conversation about Tylenol PM. Many people expressed surprise after learning about the risks tied to their nightly routine.
He explains that while this sleep aid with acetaminophen may work in the short term, it’s not safe for ongoing use. He urges everyone to check the label and consider alternatives, especially if they are taking the medication regularly.
As his message spreads, more people are asking for clearer product warnings and better public education about the safe use of OTC sleep and pain medications.
Safer Ways to Treat Pain and Sleep Issues
If you are relying on Tylenol PM regularly, it’s time to consider safer options. There are many ways to treat pain and sleeplessness without putting your organs at risk.
For Pain:
Stick with plain acetaminophen or ibuprofen and follow dosage instructions
Try topical creams for muscle aches or joint pain
Add gentle stretches or physical therapy to your daily routine
For Sleep:
Follow a healthy bedtime routine with consistent sleep and wake times
Limit screen time and keep the bedroom quiet, cool and dark
Use melatonin occasionally under a doctor’s advice
Explore cognitive behavioral therapy for insomnia, a proven drug-free approach
Always talk to a healthcare provider before using any over-the-counter sleep remedy on a regular basis.
Final Thoughts: Use Tylenol PM with Caution
Tylenol PM continues to be one of the most used OTC sleep and pain medications. But regular use may lead to serious consequences, including liver and kidney damage.
If you find yourself reaching for it night after night, take a step back. Are you treating a short-term problem or risking long-term harm?
Read labels carefully, understand what you’re taking and limit use to occasional situations. If you’re struggling with chronic pain or insomnia, seek medical advice.
Choosing a safer solution today can help protect your health in the future.