Stars Who've Spoken About Ozempic — and What They've Said

One of the hottest topics in Hollywood: The type 2 diabetes drug Ozempic and its fellow semaglutide drugs, such as Wegovy, as well as similar GLP-2 drugs containing tirzepatide, such as Mounjaro and Zepbound. The use of either prescription — which Dr. Ania Jastreboff tells PEOPLE are "nutrient-stimulated, hormone-based medications" that target the brain and affect satiety. As a result, the GLP-1 drugs have become popular in Hollywood for weight loss both for those who only need to lose a few pounds as well as for those who have been open about their long-term weight struggles.

"The Hollywood trend is concerning," Dr. Caroline Apovian, co-director of the Center for Weight Management and Wellness at the Brigham and Women's Hospital in Boston, tells PEOPLE of the target audience for the drugs. "We're not talking about stars who need to lose 10 lbs. We're talking about people who are dying of obesity, are going to die of obesity."

Read on for what stars have said about the meds.

Savannah Chrisley

"People are made to feel so much shame. People do it for health-related reasons. I personally did it because I was pre-diabetic ... I lost 40 lbs."

Joy Behar

Bunny xo

“Honestly, I just went through a bout of suicidal ideation from using a GLP-1, which, I really think people need to talk more about this. I just told them, I said, ‘I haven't had suicidal ideation like this since 2020.’ That's how bad it was.”

Vanessa Williams

“It’s a game‑changer. When I turned 60, I was like: ‘I want to be here for a long time, and I want to look my best. So what am I going to do?’

"My 50s were hard. I started perimenopause in my late forties but suddenly, at 51, it’s crazy how your body changes. You feel out of control because you’re working out the same way, eating the same, and your body is not reacting the way it used to."

Oprah Winfrey

"After knee surgery, I started hiking and setting new distance goals each week. I could eventually hike three to five miles every day and a 10-mile straight-up hike on weekends. I felt stronger, more fit and more alive than I’d felt in years.

"I eat my last meal at 4 o’clock, drink a gallon of water a day, and use the WeightWatchers principles of counting points. I had an awareness of [weight-loss] medications, but felt I had to prove I had the willpower to do it. I now no longer feel that way.

"I now use [an unnamed weight loss drug] as I feel I need it, as a tool to manage not yo-yoing. The fact that there's a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for. I’m absolutely done with the shaming from other people and particularly myself."

— to PEOPLE in December 2023

"In my entire life, I never dreamed that we would be talking about medicines that are providing hope for people like me who have struggled for years with being overweight or with obesity."

— during her open-dialogue conversation An Oprah Special: Shame, Blame and the Weight Loss Revolution on ABC in March 2024

"I knew that admitting to being on medication was going to be a big freaking deal. I knew I was going to get lots of pushback. And I did." to PEOPLE in her Dec. 2025 cover story. 

Kate Winslet

“It is devastating. If a person’s self-esteem is so bound up in how they look, it’s frightening.”

"And it’s puzzling because I have moments when I think it’s better, when I look at actresses at events dressed how they want, whichever shape. But then so many people are on weight-loss drugs. It’s so varied. Some are making choices to be themselves, others do everything they can to not be themselves.”

“And do they know what they are putting in [their bodies]? The disregard for one’s health is terrifying. It bothers me now more than ever. It is f------ chaos out there."

— Kate Winslet in a December 2025 interview with the Sunday Times.

“Oh, my God. This sounds terrible. Let’s eat some more things!”

— to the New York Times, after they explained the drug to her, in March 2024

Ashley Tisdale

"A few years ago, almost nobody in LA would admit to using Ozempic. I'd hear whispers about people doing 'the jab,' and then I learned that some people were using diabetes medicine off-label to lose weight. But it was all very mysterious and nobody was super-open about it."

"Times have changed. Now it feels like everyone's either on a GLP-1 drug or talking about starting it. I'm all for transparency and openness, but I've had moments when I've wondered, Is everyone using Ozempic except me?"

"To be clear: I have absolutely ZERO judgment toward anyone using Ozempic or other similar medications. Zero … But when I see people who are already thin signing up for it, I can't help but think of how body trends keep shifting. In the 2000s it was big boobs, then suddenly flat chests were in. The 2010s brought body positivity, and now it's like we're back to chasing ultra-slim everything. We keep moving the goalposts and it's exhausting."

Jelly Roll

"We're not against Ozempic or any of that stuff. Every doctor I've talked to is for it. They said it helps. I just was afraid of it.”

"As a singer, few things scare me more than acid reflux. Like, you'll watch me get up out of a bed, I'll burp and wake up panicked and go take something for it. You know? Because that stuff will just rip the vocal cords.”

“I just could not afford any acid reflux. So I want to be very clear that I've done it naturally, but it wasn't out of stubbornness or trying to prove a point. If it helps you, go get it. But for me, I was just petrified of the side effects of it."

— explaining how acid reflux, a common side effect of Ozempic, was the reason he never got on it while on his wife's Dumb Blonde podcast.

Jenna Bush Hager

“Food is so good! I mean I haven’t done it because I want to eat, you know? Among other reasons.”

— on the Sept. 17 episode of Today with Jenna & Friends.

Chrissy Teigen

“I first started taking ozempic after the loss of our Jack - there I was, existing in a body that didn’t feel like mine, with absolutely nothing to celebrate - just the constant reminder that this body that once carried life for 20 weeks, was now just a…sad reminder."

Serena Williams

“I never was able to get to the weight I needed to be no matter what I did, no matter how much I trained. It was crazy because I'd never been in a place like that in my life where I worked so hard, ate so healthy and could never get down to where I needed to be at.”

“I had never taken shortcuts in my career and always worked really hard. I know what it takes to be the best. So it was very frustrating to do all the same things and never be able to change that number on the scale or the way my body looked.”

“I lost over 31 pounds using my GLP-1 and I was really excited about that weight loss.”

“GLP-1 helped me enhance everything that I was already doing — eating healthy and working out, whether it was as a professional athlete at the top level of tennis or just going to the gym every day. So I think that it’s important for everyone to hear my story. And I feel like there's a lot of people that can relate.”

Lizzo

"I've tried everything. It’s just the science, for me, calories in vs. calories out. Ozempic works because you eat less food. It makes you feel full. So, if you can just do that on your own and get mind-over-matter, it’s the same."

— on the Just Trish podcast, saying she has tried GLP-1 drugs, but decided to focus on controlling calories with "mind over matter" instead — including ceasing to be vegan because she wasn't feeling full enough

"If I did all of this on Ozempic, if I did all this with surgery, I would be just as proud of myself, because this s--- is hard. Everyone who’s ever been in a bigger body in this current version of society knows that this s--- ain’t easy. Existing isn’t easy."

— on her weight loss, to Women's Health U.K.

Lauren Manzo

"I do think that people shouldn't abuse [Ozempic] ... I think it's being abused because I see people, Housewives, that are posting and you literally see their ribs, and it's sad because you were already skinny. And that puts a bad thing for somebody like me who has suffered from high blood pressure and anxiety from being super heavy and depression.

"People that are already 130 lbs. and just want to lose 10 more and they want to stay on it. That, I don't respect. I understand people with diabetes need that, and I respect that. I do think this will be really helpful for people like me, who've struggled their whole lives and had not only physical but mental issues as well from their weight."

— when talking about her experience on Mounjaro — an FDA-approved prescription medication for people with type 2 diabetes similar to Ozempic

"I really believed [Mounjaro] saved my life. What they say about food noise – I had never heard that term."

— on losing another 50 lbs. on Mounjaro, to PEOPLE

Candace Cameron Bure

“You see so much of Hollywood getting skinny all of a sudden, and there's a little place of jealousy as a woman that it's like, ‘Oh, this is the easy way out.’ And yet I know that's not true for everybody. And I really had to just take a step back and say, ‘Why am I jealous? Why am I feeling this way?’ "

“Whether weight-loss drugs are included for you in that journey to be your best, that's up to each individual. 'I kind of let that go.' "

— on GLP-1 medications, to Fox News Digital

Catherine Lowe

"It's been hard to watch the Ozempic craze. It's been, I'm sure, triggering for a lot of people, but there's a healthier route, and I think if you're willing to stay on track at something for a longer period of time, you'll probably see a healthier lifestyle in general."

— in an interview with husband Sean Lowe on FOX News

Amanda Bynes

“Oh, I’m going on Ozempic. So excited. I’m 173 now so I hope to get down to like 130, which would be awesome so I look better in paparazzi pictures. I will post about my Ozempic journey of course.”

— in a video shared to her Instagram Stories

Rosie O'Donnell

“I can't believe this is me now #mounjaro #weightloss #bodydismorphia."

-in the caption of an Instagram shot of herself, several months after revealing that she was on Mounjaro to control her diabetes, but had experienced significant weight loss as a result

Renee Graziano

"I’ve battled self-criticism in the past! Ripped myself down to the ground!! I truly was so sick and tired of my life and my inability to lose weight so I thought I’d eat until I felt better THAT NEVER HAPPENED, I felt like I was constantly falling short—of how I “should” look, feel, and keep up with what society tells us is acceptable.

That’s why, when I see photos that show the real, visible change, My clear eyes and genuine smile I have to share. I want everyone to know if I can do it you can do it! it’s all possible!!

The substantial amount of weight that I have lost really has made me feel and look younger than I have in a long time. My mind is clear and My body has transformed, and more importantly, so has my confidence.

Whatever goal you’re working toward, know this: you can do it. Be patient. Be kind to yourself. And don’t give up.”

—on taking Mounjaro for a 52-lb. weight loss, on Instagram

Sophia Umansky

"I am very lucky that I have so much hair because at the rate that I have been losing hair, I'm gonna be bald in about a week. I started Mounjaro about four months ago and I would say for the past three weeks to a month, I've noticed a dramatic hair loss situation..."

"I don't think it's a direct result of the medication, I think it's a direct result of rapid weight loss because of the medication and not eating enough vitamins, protein and all that kind of stuff. I feel like at the beginning of starting this medication, I was just making sure I was eating enough. I wasn't really thinking about enough protein or vitamins."

— in a TikTok video chronicling her hair loss

Eric Stonestreet

“It’s a game changer. It has just been incredible. It's changed my lifestyle, changed my approach to eating, changed my approach to exercise.”

“I felt like, well, if I don't do something along with it, I'm disappointing it. I'm letting it down. Here these people have invented this incredible thing that clearly does its part. Now I need to contribute my part. And it turns out that when you do that and make some really great choices, weight loss is also a byproduct of that.”

—on taking Mounjaro to manage his health and weight, to PEOPLE

Meghan Trainor

"No, I don’t look like I did 10 years ago. I’ve been on a journey to be the healthiest, strongest version of myself for my kids and for me. I’ve worked with a dietician, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I’m so glad I did because I feel great.

Here’s to celebrating talent, growth, and the power of putting yourself first. Let’s keep shifting the convo to what REALLY matters."

— on Instagram, after people kept commenting about her appearance at Billboard's 2025 Women in Music Awards.

Josh Gad

"[The GLP-1 drug] has suppressed, in a great way, that noise ... when I wake up, I feel hunger pains — and so much of that is psychological, right? — and what this does is it takes away that signal.

I've always been the funny fat guy. Can I be the funny skinny guy? Can I be the hot leading man? I don't know that people would accept me as those things.

It's a miracle drug ... My primary goal is, I want to be there for my kids. Everything else is bulls---."

— on Armchair Expert about losing 40 lbs. on the medication

Harvey Fierstein

“People don’t understand that being fat is not a choice. It’s something that your body is out of whack and [weight loss medication] puts your body in whack.

What’s different is what the drug actually does for you, which is: I don’t feel like I’m dieting. I feel like a normal person. I can go and have dinner with friends and not have to eat every piece of bread on the table, and then not go have ice cream when I’ve done with dinner.”

— to Page Six about his use of Zepbound

Elon Musk

“Ozempic Santa."

-on X (though he later added that he found Mounjaro to be more effective in his weight loss)

"Nothing would do more to improve the health, lifespan and quality of life for Americans than making [GLP-1 drugs] super low cost to the public."

Jim Gaffigan

"I'm just grateful because it's such a better life."

"I had very low expectations because I did know someone that had tried it and they were like, 'Oh no, I was just nauseous for a week.' And then I thought my true joy of eating would overpower anything."

— to PEOPLE, explaining how he lost 50 lbs. using Mounjaro

“I have gotten skinny. And it’s none of my own willpower. It’s a shot in the stomach. That works wonders. I don’t know why people are afraid to admit it. It seems strange.”

— on The View

James Corden

“I tried Ozempic, and it won’t be surprising to you when you look at me now, that it didn’t really work. I tried it for a bit and then what I realized was I was like, ‘Oh no, nothing about my eating has anything to do with being hungry.’ All this does is make you feel not hungry. But I am very rarely eating [just because of hunger].”

— on the Sept. 19 episode of his This Life of Mine podcast.

Brooks Nader

"Suspect randomly lost 20 pounds; says it's from working out, but she got on Ozempic,"

— one of Brooks Nader's sisters, in a TikTok video where they were doing the "suspect" challenge.

Fat Joe

“Ozempic says you may only have two pieces of your favorite stuff.”

— to Us Weekly while discussing how both the prescription medication and cutting carbs have helped maintain his 200-lb. weight loss

Kathy Bates

“There’s been a lot of talk that I just was able to do this because of Ozempic, but I have to impress upon people out there that this was hard work for me, especially during the pandemic. It’s very hard to say you’ve had enough.”

— to PEOPLE, while clarifying that in addition to the 80 lbs. she lost over the past seven years through changes in her lifestyle and diet, she lost another 20 lbs. on Ozempic.

Bella Thorne

"So, I haven't been feeling good about my body for a while and especially with everybody on Ozempic — it's, like, setting all these crazy beauty standards that nobody can keep up with unless you're on Ozempic ... I'm finally feeling good, so Ozempic, you can [middle finger raised] off."

— in a video shared to her Instagram Story

Ashley Benson

“I know a lot of people take Ozempic and that's totally fine. To each their own. But don't discredit people who also work very hard to get their body back like I've done with mine ... Getting back to work forced me to focus on my health and working out and I wanted to feel confident and good about myself."

— on her Instagram, after commenters speculated she'd taken the medication postpartum

Ice Spice

"I wish y'all never learned the word Ozempic. That's one thing I wish. Oh my God, like, what even is Ozempic? What the f--- is that? Genuinely, what is that?

Like, you lazy ass bitches never heard of a gym? It's called the gym. It's called eating healthy. It's called being on tour. Like, what the hell? Maybe if I was sitting home all day, it would be easier to stay big."

— during an X Spaces chat

Macy Gray

“Quietly, I’m kind of a vain person. I’ve gained a lot of weight over the past couple years, and this is right about the time when everybody starts talking about this Ozempic.

So, I thought, okay, I’m not taking [the weight] off the right way, let me see if I can get one of these Ozempic. I was actually trying to take it off [the weight] before the show because I didn’t want to be super fat on TV, but here we are.”

— During an episode of MTV's The Surreal Life

Kandi Burruss

“Last year, I tried it. I saw so many people who were trying it and losing weight. So I was like, ‘Okay, I’m going to try this.’ And I didn’t lose any weight.

My doctor was like, ‘I don’t know what the problem is, I’m not seeing this in other people,' ...It didn’t curb my appetite. I know some people are like, ‘Oh, I can’t eat.’ Not me! I was eating appetizers, a regular meal and dessert, okay? It didn’t stop anything for me.

When you see it worked for other people and it doesn’t work for you, it makes you depressed. Realistically, it makes you feel like, ‘What is wrong with me? Why is it not working for me?’”

— on PageSix’s Virtual Reali-Tea podcast

Spencer Pratt

“I’m not trying to get Ozempic face. I’m not trying to be on Page Six coming out of a place, getting papped and looking all Skeletor [and] spooky.”

— explaining why he won't use semaglutide to help him lose weight, on the Page Six Virtual Reali-Tea podcast

Nigella Lawson

“I read something once where someone said, ‘I was on Ozempic and it was the first time I didn’t think about food all the time,’ and I thought, I can’t imagine anything worse than that. I take great pleasure in thinking about food all of the time.”

— to the New York Times

Caroline Stanbury

“After 40, we all know, it’s very, very hard to lose weight. But I met so many 40-year-old women going, ‘How have you done it?’ And I don’t want to lie to you … I used Ozempic, which I think is one of the best tools if you’re able to use it. What did Kate Moss say? ‘Nothing tastes as good as skinny feels.’ There’s something to be said for that.”

— on the Uncut & Uncensored with Caroline Stanbury podcast

“Ozempic, I have to say … is an incredible tool. Why do you need to be miserable if you can get yourself back to where you were? I didn’t want to be different. I didn’t do my face to look like a supermodel. I wanted to be me, but younger.”

— to Us Weekly

Dr. Phil McGraw

“If someone is using a tool to help them get back to health, help them lose weight, which takes the pressure off their heart, this isn’t something they should be criticized about. I say more power to ‘em and don’t feel guilty about it and don’t be shamed from people saying something about it. Tell them to mind their own damn business.”

Captain Lee Roshbach

“No. What you see, that’s what you get. I feel fortunate to be part of the lucky gene pool and what isn’t affected by the lucky gene pool I can usually affect by diet and working out.”

— on whether he would use semaglutide to stay in shape, via the Page Six Virtual Reali-Tea podcast

Kelly Clarkson

"Mine is a different [drug] than people assume, but I ended up having to do that too because my bloodwork got so bad."

"My doctor chased me for two years, and I was like, 'No, I'm afraid of it. I already have thyroid problems.' Everybody thinks it's Ozempic, but it's not. It's something else."

"My heaviest, I was like 203 [lbs.] And I'm like 5-ft.3-in. and a half."

— to Whoopi Goldberg on an episode of The Kelly Clarkson Show. Clarkson did not reveal the drug that she was taking but explained that the medication is "something that aids in helping break down the sugar," as her body "doesn't do it right."

Khloé Kardashian

"Let's not discredit my years of working out. I get up 5 days a week at 6am to train. Please stop with your assumptions. I guess new year still means mean people."

— responding to an Instagram user who suggested she was on Ozempic

Margaret Josephs

“After menopause, it’s so hard to lose weight. And then you’re shamed for it if you’re heavy."

“It shuts off that food noise, my blood work is great. [Before Ozempic] I couldn’t do anything. It doesn’t matter if I was eating right or exercising so I don’t know why there’s any shame in it if it’s helpful to people.”

— to Sherri Shepherd on her podcast Sherri, after admitting she had struggled with her weight after menopause

Jon Gosselin

“You know what’s annoying? The regret of not starting it 10 years ago. I feel amazing! Like, why didn’t I do this sooner? Maybe it wasn’t the right time.”

“It’s really nice because it helped me stop drinking and it helped me get my appetite under control with less eating. I was able to really refocus my diet that way, I just focused on consuming what I need to consume in a healthy manner.”

— to Page Six at the BHRC West Hollywood grand opening in April 2024

Jamie-Lynn Sigler

"I'm annoyed at myself that I'm admitting this and I'd like to get to the bottom of why I'm a little triggered about all the Ozempic stuff. It's upsetting me. I wish I didn't care. It felt like we were on this road to solidifying body positivity, and every shape and size and color, and everyone's looking the same now."

"For women out there listening, the thinner your face is, the older you look, okay? Not that looking old is bad!...Aging gracefully is beautiful."

— to Christina Applegate on their podcast, MeSsy.

Rebel Wilson

“Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good."

“Basically no one apart from my mom wanted me to lose weight. People thought I’d lose my pigeonhole in my career, playing the fat funny character, and they wanted me to continue in that.”

“I feel strongly that young women shouldn’t try to obsess over looking like Victoria’s Secret models — they should just look like themselves. I know that my relationship with food is complicated."

— to The Sunday Times in March 2024. Wilson also admitted that she is no longer on a weight loss drug, and that she is happy with her "still curvy and solid" current weight

Christina P.

“The doctor goes, ‘You know what, since you ate right through it last time, I'm going to start you on a higher dose.' And I'm like, ‘Alright, fair enough. I'm a pig.’

“I'm like, ‘Dude, I can't even [eat]. I feel nauseous. I can't even eat this bread. My mouth is dry. I feel like I'm gonna throw up.' And then I wake up in the middle of the night, like, super nauseous.

“I'm like, ‘This is working this time. I'm down, like, 3 lbs.'

"I take a bite. And I'm like, ‘Oh, I'm full. This feels great.’ You know?”

— while cohosting the Your Mom's House podcast with her husband Tom Segura. After a nurse friend came to visit, Christina P found out she had taken "enough [Ozempic] for, like, a 500-lb. man," per her friend.

Tori Spelling

“I did Mounjaro and everyone admits it now. It’s a different time so I don’t feel shamed saying that.

“I did whatever anyone told me to do that was safe and it just wasn’t working. The weight wouldn’t come off.”

— while discussing her usage of the tirzepatide and hormones on her podcast, misSPELLING, after admitting she had struggled with her weight after the birth of her fifth child, son Beau, in 2017. Spelling also said she is no longer on the drug.

Mama June Shannon

“As you know, back in May 2015, I had gastric sleeve surgery. I used to weigh 550 lbs. and on my own, I went from 550 lbs. to 311 lbs. on the day I had my surgery. And in six weeks, I went from 311 all the way down to 195. Since then, I kinda kept off the weight. I stayed at like 130, 140, 150 lbs.”

“But I have noticed over the last year and a half that I’ve really put on weight."

“I decided to go with semaglutide a couple of months ago through my main doctor,” she said, urging people to be safe and talk to their primary care physician before taking the medication.

— in an Instagram video posted on April 16, 2024. In the video, Mama June's husband even gives her her first injection

Billie Jean King

“I'm a binge eater. Every morning I wake up, I tell myself I have an eating disorder. I still go to therapy. I still think about it. It's interesting with the new injections, you know, with the Ozempics of the world. It's very interesting because my doctor wants me to try it.”

“My therapist asked me, ‘Has it quieted your mind?’ With an eating disorder, I have two voices in my head sometimes that argue. Let's say I want a quart of ice cream. One side will say, ‘Yeah, baby, I'm going to have that ice cream no matter what.’ And the other side says, ‘No, don't do that. It's not healthy. You don't need it.’ So I have this discussion that goes on in my head, and sometimes it's very elevated.”

“It was such a great question because if [weight loss medication] does quiet the voices – if that's a part of it – now I’m [interested in] it because that would be really great. Because that gets exhausting and tiring. And I don't wanna fight over these things.”

— while discussing her use of weight loss injections and her eating disorder on Julia Louis-Dreyfus' Wiser Than Me podcast

Tracy Morgan

"I went and got a prescription, and I got Ozempic. And I ain't letting it go ... It cuts my appetite in half. Now I only eat half a bag of Doritos."

— on Today with Hoda & Jenna in August 2023

“I’ve learned to out-eat Ozempic. I out-ate Ozempic. I’ve gained 40 pounds."

— on The Tonight Show Starring Jimmy Fallon in March 2024

Terry Dubrow

“I’ve tried it. I thought it was amazing. I didn’t have that much weight to lose. But I wanted to try it because so many of my patients were on it and I wanted to see what it was like when you’re not diabetic and you only have 10-15 pounds to lose.”

— speaking to Page Six after trying Ozempic in January 2024

"How am I doing off Ozempic? I'm overweight and chubby. There's more to love, but I'll tell you something: I'm off it, but I plan on going back on it when it's appropriate. Like we have a vacation and after that I'll come back. It's like the new Botox, Ozempic. I love it. It's so good."

— speaking to E! News in March 2024 about how he feels after stopping the medication

Al Roker

"Everybody’s struggling with it and we’re still trying to figure it out. But no shame, no game. Just stay within your lane and don’t give anybody a hard time."

— addressing judgement surrounding weight loss drugs in regards to Winfrey's televised discussion in March 2024

Whoopi Goldberg

"I will tell you, I weighed almost 300 lbs. when I made [2022 film] Till. I had taken all those steroids, I was on all this stuff, and one of the things that’s helped me dropped the weight was the Mounjaro. That’s what I used."

— on an episode of The View following Winfrey's ABC special

"First of all, it's all the weight I've lost. I've lost almost two people. I am doing that wonderful shot that works for folks who need some help, and it's been really good for me."

— on an episode of The Kelly Clarkson Show, after Clarkson complimented Goldberg's appearance.

Sunny Hostin

"During COVID, I gained 40. lbs. All I did was eat ... I love to cook, and I found out, I love to eat. And I was horrified about the fact that I would have to come out on air. So I also took Mounjaro.

"I found that my cholesterol went up to 200 when I gained the extra weight. And I use Mounjaro and my cholesterol is 140 now. I feel better, I think I look better, and that’s what this is about for people."

— on an episode of The View following Winfrey's ABC special

Stephen Fry

“I tried Ozempic years ago; I'm an early adopter of these things. I happened to be in America, and I'd read about it, and I asked my doctor in America, my physician as they like to call them, and he said, ‘I think I can get you some.’ He tried me on it, and the first week or so, I was thinking, ‘This is astonishing. Not only do I not want to eat, I don't want any alcohol of any kind. This is going to be brilliant.’

“Then I started feeling sick, and I started getting sicker and sicker and sicker. I was literally throwing up four, five times a day and I thought, ‘I can't do this.’ So that's it.”

— speaking to host Ruthie Rogers on her River Café Table 4 podcast in March 2024

Rob Lowe

“I see people who are taking all the new weight loss drugs and that's great, and it's really changed their lives. But my concern always is, okay, now what? What’s the plan for the longevity of everything? I never ever talk about diets, I talk about lifestyle."

— to PEOPLE in February 2024

Kelly Osbourne

"I think it's amazing. There are a million ways to lose weight, why not do it through something that's isn't as boring as working out? The people who hate on it the most are the people who are secretly doing it or pissed off that they can't afford it. Unfortunately, right now it's something that is very expensive but it eventually won't be because it actually works."

— to E! Online in February 2024

Sharon Osbourne

“You can’t stay on it forever. I lost 42 pounds now and it’s just enough.”

— on an episode of Piers Morgan Uncensored where she opened up about her previous use of the drug, and added "I didn’t want to go this thin. It just happened."

Heather Gay

“I've been on it for a long time, but hadn't really seen much results. And I haven't had massive results, but enough for people to notice, which is great."

— to PEOPLE at Variety’s Women of Reality TV event in November 2023.

Garcelle Beauvais

“Don’t even start with that Ozempic thing I’m not playing with that!!!”

— Iin response to an X commenter who shared a questioned if the reality had been using the drug.

Claudia Oshry

"You thought they were going to make a weight loss drug and I wasn't going to take it? You're dumb. Of course, I'm f—ing taking it."

— on her episode of her The Toast podcast while explaining that she initially felt embarrassed to admit she had been taking the weekly injections.

Amy Schumer

“Like a year ago, I tried it. I was one of those people that felt so sick and couldn’t play with my son. I was so skinny and he’s throwing a ball at me and [I couldn’t].”

— during an appearance on Watch What Happens Live with Andy Cohen

Stassi Schroeder

“Oh, my God, I really want to try it when I give birth. The amount of times I’ve researched this being like, ‘I mean, I think it’s safe and healthy. Like, I think it’s good for you. It’s like taking vitamins.' ”

— discussing Ozempic on an episode of the Call Her Daddy podcast. Host Alex Cooper followed up the statement by jokingly giving a disclaimer that "nothing that was said on this podcast medically" should be understood as advice

Emily Simpson

"So I did. I did that in December for one month," Simpson explained and added that her bad habits "went away... It made me more conscientious of what I was eating and so that was a really great kick start for me."

— during an appearance on SiriusXM's Jeff Lewis Live where she spoke candidly about her decision to try Ozempic at her doctor's suggestion

Golnesa 'GG' Gharachedaghi

“When I started Semaglutide shots, I was 138 lbs. Now, I’m about 110 lbs. As you can see, I've lost a little more weight than I was anticipating to lose. I decided I’m only gonna weigh myself on the days of my injections just to document it. And on April 30, I got on the scale and I saw 111 lbs. That’s when I knew, it’s time to cut back. That’s when I started cutting down on units and going backwards and backwards until finally now, I’m just on maintenance.

“Will I come off of it? Maybe. Will I gain it all back? Maybe. But for now, I’m enjoying the way I look. I’m enjoying what it’s doing for me. I encourage it to anybody who’s having a hard time losing weight and wants the ‘easy route.’ Summer’s around the corner. I’m not trying to stress that being skinny is what you should do, but truth is, some of y’all want to do it. So I’m talking to you guys… not the haters. To the haters, kiss my ribs b—.”

— in a lengthy Instagram video answering questions about her weight loss journey

Anthony Anderson

"I will say this, it's creating a shortage for those of us who need the medicine that we need and not for weight loss issues, but for our health."

— when talking to PEOPLE about how the drug's newfound popularity impacts those like him who are living with type 2 diabetes

Jessica Simpson

“Oh Lord… it is not."

— while addressing assumptions that her weight loss is due to the use of a semaglutide in an interview with Bustle

Jenny McCarthy

“You know what, I think whatever suits someone’s needs. If you fall into the category where you think it’s right for you, I am not gonna shame you. I’ll support anything people want to do. For me in particular, I knew that it was not permanent, I knew that a lot of people that go off of it, they regain their weight.”

— while discussing why she's "not an Ozempic person" in an interview with US Weekly

Mark Wahlberg

"Everybody has their own path. I don't knock anybody for making their own choices. But I prefer, and I've seen lots of people accomplish amazing things, ordinary people doing extraordinary things on a fitness base, and they're now encouraging other people that look like them. That's what I'm into."

— while discussing how he feels about those deciding to use semaglutide for weight loss in an interview with Page Six

Raven-Symoné

"I think it's very important we understand certain medications are made for certain people and to not take that away just for glamazon purposes.

“Do what you gotta do. Just make sure you save some medication for the people that actually need it," she added

— in an interview with E! New

Keke Palmer

"Sounds like it's a slay honey, 'cause girls have been out here killin' it with it, but for me, I would say 'Nay' because I always feel like when something sounds too good to be true — it usually is.

"It might do something and then next thing you know, I've got something growing, you know, under my armpits, like I don't know where... where you pushing this fat at, where you taking, where you pulling from — I don't want any side effects, so — but the girls are killin' it."

— during a round of "Slay or Nay" for PEOPLE's Beautiful Issue

Padma Lakshmi

"You gotta be careful what you do with your body. On Top Chef I eat a lot, and I understand the tendency [to want to follow a weight loss trend]. But also the pressure for women in media is much different than men in media. So we have to maybe look deeper to the reasons why, as a society, not just put it on the shoulders of the women who just want the same opportunity that men get.

"We just want an equal shake. We have to look good, we have to sound good, we have to be strong but not too strong, we have to be vulnerable but not too weak. And it can feel like a really dichotomous, tall order.

"So, I think we have to be kinder to each other and to ourselves."

— to reporters at the 2023 Time100 gala

Ariana Huffington

"Well, if people are diabetic it can really help them. But I think people forget that you also need to eat better. You know, if you are on Ozempic and eat junk, processed foods, too much sugar, you are not going to really change your eating habits. And we know that what leads to disease are ultra processed foods and sugar."

"So, learning to also change your food habits is key."

— to PEOPLE at the 2023 Time100 gala

Sophie Turner

"WTF"

- on her Instagram Story, in response to photos of semaglutide advertisements posted inside a New York City subway station, per The Independent

Dolores Catania

"I wasn't going to come to [the] reunion looking bigger than anyone else."

— to Andy Cohen on WWHL, confirming she uses a weight loss drug

"I'm down 20 pounds. I'm being realistic. Right now, I'm 137. I was 157 when I started. I jumped to 163 - I was going there. Like, I was gaining weight every month. So then when I finally kicked in... the problem is, like, if you don't start it, it takes time to work. It doesn't happen overnight. It doesn't come off easy. I took Ozempic, stopped and then began Mounjaro,” she explained. “I was medically prescribed for both because I am insulin resistant/pre-diabetic and have a thyroid issue. You know, everyone's losing so much weight [on it]. It's questionable - what are the repercussions of this when everyone's done? Is there side effects? All the doctors that I spoke to said 'no.'

"I stopped taking it because it was expensive and everything. But being healthy and living a healthy lifestyle is cheap - it's free!" she insisted. I work out regularly. There is no easy fix for weight loss and I have to watch what I eat."

— to the U.S. Sun in 2023.

“I don’t know why because there’s no shame in it. If a doctor gives it to you, if you’re doing things right, you’re becoming healthier by losing weight. It’s a bunch of great things that come along with this.”

"This is my high school weight. I’m not parting with it and I’m gonna be honest because it’s right."

— to Sherri Shepherd on an episode of Shepherd's self-titled talk show Sherri about why some celebrities keep their medication usage quiet.

Julia Fox

"All these people are coming for me saying that I take the weight-loss things … people are saying that I'm taking Ozempic. I'm not, and I never have. I would never do that. There are diabetics that need it."

— to Entertainment Tonight in March 2023

Meghan McCain

"I was even offered a black market freebie by someone with 'extra shots at home.' ... Let me make one thing very clear. I'm not taking it. I refuse. There's a clear moral issue here. It's hard to take a drug because swimsuit season is around the corner, while others need it to stay alive. And how can this be healthy? There ain't nothing worth having that's easy to get."

— in an op-ed for the Daily Mail about being offered weight loss drugs while postpartum

Jillian Michaels

"[I've] taken at least eight family friends' parents off of this drug. The truth of the matter is, Ozempic has some pretty significant side effects. Do your homework on it. The results are not lasting, in very large part,"

— to PEOPLE

Patti Stanger

"This is the Hollywood drug ... It's nationwide. I have friends in Miami, I have friends in New York who are doing it."

— to the Wall Street Journal in October 2022, before opening up about her own experience with Ozempic and Mounjaro on the Behind the Velvet Rope podcast in February 2023

Katie Maloney

"I say everyone do what you want to do. Understand the risks, and if it's right for you, it's right for you. I think the expectations [for women to be thin] are always going be there whether or not there's like this miracle drug or not. The pressures are always going to be there. So thanks, Hollywood, thanks media, thanks society for keeping it going. But I just think, you know, if it makes you happy, follow your bliss."

— to PEOPLE at the premiere of Vanderpump Rules season 10

Lala Kent

"Stop taking it for weight loss. Enough already. I think that Hollywood is all sorts of f—ed up. We've got to do better. I think there's a lot of things that need to change and it starts with us and there are times where I roll my eyes and say, 'F—ing do better, all of us. We all need to participate in becoming better examples for our children in the outside world."

— to PEOPLE at the premiere of Vanderpump Rules season 10

Kyle Richards

"I cannot stand people saying [I'm taking Ozempic] because people that know me know that I'm up every day at like 5:30 a.m. 6 a.m. at the latest… I'm in the gym for two hours. I really put a lot of effort into my diet and exercise and taking care of myself, so when people like to think I took the easy way out, it's frustrating."

— to Extra at the American Heart Association's Go Red for Women Red Dress Collection concert in New York City, after she recently clapped back at commenters who suspected she's using the drug after posing a bikini selfie

Chelsea Handler

"My anti-aging doctor just hands it out to anybody. I didn't even know I was on it. She said, 'If you ever want to drop five lbs., this is good.'

"I came back from a vacation and I injected myself with it. I went to lunch with a girlfriend a few days later, and she was like, 'I'm not really eating anything. I'm so nauseous, I'm on Ozempic.' And I was like, 'I'm kind of nauseous too.' But I had just come back from Spain and was jet-lagged.

"I'm not on it anymore. That's too irresponsible. I'm an irresponsible drug user, but I'm not gonna take a diabetic drug. I tried it, and I'm not gonna do that. That's not for me. That's not right for me.

"I've injected about four or five of my friends with Ozempic because I realized I didn't wanna use it cause it's silly. It's for heavy people. Everyone is on Ozempic. It's gonna backfire, something bad is gonna happen."

— on Alex Cooper's Call Her Daddy podcast

Remi Bader

"[My doctors] said I need this. And I had a lot of mixed feelings. A few months later I went off it and got into the bad binging.

"I saw a doctor and they were like, it's 100 percent because I went on Ozempic. It was making me think I wasn't hungry for so long, I lost some weight. I didn't wanna be obsessed with being on it long term. I was like, I bet the second I got off I'm gonna get starving again. I did, and my binging got so much worse. So then I kind of blamed Ozempic. [I] gained double the weight back."

— on Amanda Hirsch's Not Skinny But Not Fat podcast

Jackie Goldschneider

"An eating disorder in a needle. [It's] sad and sickening. [I] can't imagine what will happen if people need to suddenly stop."

— on Instagram

"I'm horrified by it. I'm not so much horrified by people wanting to lose weight — that has always been a universal thing — but I'm very very scared of what will happen if and when people have to go off this drug.

"It's just going to be a massive number of people who gain a huge amount of weight and suddenly don't know what to do with themselves. I'm just afraid of that day. There's going to be a lot of people with eating disorders. You start dropping massive amounts of weight. That's so addicting. That's how I spiraled into anorexia. You get addicted to this new body and to the attention that comes with it.

"A lot of people in the Housewives world are on Ozempic. A lot of my friends are in the Housewives world, so it was tough for me to come back and suddenly no one's eating when we go out to dinner."

— on the Page Six Virtual Reali-Tea podcast

Andy Cohen

"Everyone is suddenly showing up 25 pounds lighter. What happens when they stop taking #Ozempic ?????"

— on Twitter

Elon Musk

"Fasting ... And Wegovy."

— replying to a Twitter user asking for his "secret" to looking "healthy"

Jameela Jamil

"I have said what I have said about the potential harm of people using the diabetes medication for weight loss only. I fear for everyone in the next few years. Rich people are buying this stuff off prescription for upwards of 1000 dollars. Actual diabetics are seeing shortages. It's a now mainstream craze in Hollywood. HOPE this doesn't end the same way we were told opioids were safe. There is little to no discussion of the side effects in any advertising online. I'm deeply concerned but I can't change any of your minds because fat phobia has our generation in a chokehold.

"I'm screaming into a void. I'm seeing people really struggle because of this stuff. It has become the exact uncontrollable wave I thought it would become and I hope that I'm worried for no reason, and that my doctors who have been advising me on this stuff are wrong, and that in 2 years nobody is saying 'F--- she was right and she tried to warn us for 6 months.'

"Wishing you all well and hope you have doctors that care about more than your size.