John Wayne Casserole

This satisfying casserole delivers all the bold flavors of the Wild West—no open flame required. Inspired by the iconic cowboy actor, John Wayne Casserole is a hearty, layered dish that has become a beloved comfort food favorite. With seasoned beef, spicy accents, a creamy layer, and a biscuit crust, it’s a go-to for feeding a hungry crowd or making weeknight dinners extra cozy.

What Is John Wayne Casserole?


It’s a warm, oven-baked dish built in layers—starting with a soft biscuit base, topped with taco-seasoned ground beef, diced tomatoes with green chilies, and onions. Continues…

That’s followed by a creamy mixture of sour cream, mayo, and cheddar cheese, then finished with more melty cheese on top. This dish is a hit at potlucks, family dinners, or anytime comfort food is calling.

 

Ingredients

Layer Ingredient Amount
Meat Layer Ground beef 1 lb
  Taco seasoning 1 packet
  Water 1 cup
  Rotel (diced tomatoes with green chilies), drained 1 can (10 oz)
  Chopped onion (optional) ½ cup
  Salt and pepper To taste
Creamy Layer Sour cream ½ cup
  Mayonnaise ½ cup
  Shredded cheddar cheese (mixed in) 1 cup
Crust & Topping Refrigerated biscuit dough (8-count) 1 can
  Shredded cheddar cheese (for topping) 1 cup

Step-by-Step Instructions


1. Get the Oven and Beef Ready
Preheat your oven to 350°F (175°C).
Lightly grease a 9×13-inch baking dish.
In a large skillet